Links checked 4/04/17.
Sometimes, Sweet’s syndrome can occur in an unusual form. This is known as a disease variant.
What is cellulitis and cellulitis-like sweets syndrome?
Cellulitis is a bacterial infection of the skin that can cause Sweet’s syndrome or look like Sweet’s syndrome (Crum et el, 2003; Dinh et al, 2007; Morgan and Callen, 2001; Resende et al, 2016; Shugarman et al, 2011).
Sweet’s syndrome that looks like cellulitis is called cellulitis-like Sweet’s syndrome. It usually affects one part of the body, and is sometimes associated with cancer and blood disorders.
What is giant cellulitis-like Sweet’s syndrome?
Giant cellulitis-like Sweet’s syndrome is a rare variant of Sweet’s syndrome that affects a larger part of the body than cellulitis-like Sweet’s syndrome, and causes giant, raised-red lesions that often have a swollen appearance (Surovy et al, 2013a). It appears to be associated with obesity, sometimes cancer and blood disorders, and one case has been reported in a patient with the autoimmune condition Sjögren’s syndrome (Kaminska et al, 2014; Surovy et al, 2013b). In 2015, the first case of histiocytoid giant cellulitis-like Sweet’s syndrome was reported in a patient with myelodysplastic syndromes and myeloproliferative disorder (So et al, 2015).
How is it diagnosed?
A swab of a skin lesion can be sent for culture to rule out cellulitis and infection as a cause (Cohen, 2007). Read more @ How is Sweet’s syndrome diagnosed?
How is it treated?
The main form of treatment is corticosteroid (steroid) therapy, but giant cellulitis-like Sweet’s syndrome has also been successfully treated with dapsone (Koketsu et al, 2014). Read more @ What is the treatment for Sweet’s syndrome?
Kaminska, E., Nwaneshiudu, A., Luzuriaga, A., Tsoukas, M. and Bolotin, D. (2014) Giant cellulitis-like Sweet syndrome in the setting of autoimmune disease. Journal of the American Academy of Dermatology, Sept;71(3): e94–e95 (online).
Morgan, K. and Callen, J. (2001) Sweet’s syndrome in acute myelogenous leukemia presenting as periorbital cellulitis with an infiltrate of leukemic cells. Journal of American Academy of Dermatology, Oct;45(4):590-5 (PubMed).
Shugarman, I., Schmit, J., Sbicca, J. and Wirk, B. (2011) Easily Missed Extracutaneous Manifestation of Malignancy-Associated Sweet’s Syndrome: Systemic Inflammatory Response Syndrome. American Society of Clinical Oncology, Aug 20; 29(24)(online).
Surovy, A., Pelivani, N., Hegyi, I., Buettiker, U., Beltraminelli, H. and Borradori, L. (2013a) Figure 2, A., B., and C., in Giant Cellulitis-like Sweet Syndrome, a New Variant of Neutrophilic Dermatosis, JAMA Dermatology, Jan; 149(1):79-83 (online).
Surovy, A., Pelivani, N., Hegyi, I., Buettiker, U., Beltraminelli, H. and Borradori, L. (2013b) Giant Cellulitis-like Sweet Syndrome, a New Variant of Neutrophilic Dermatosis, JAMA Dermatology, Jan; 149(1):79-83 (online).
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